Fall 2007 Course Descriptions

All courses below are approved to be taught in Fall 2007; however, some (or all) may not be offered this term.  The course numbers that are offered this term link to the Schedule of Classes.  Class with alternative delivery modes (Web based, cable TV, correspondence, etc) are noted in the Schedule at the section level.  The complete list below is a good indicator of what may be offered over the next few years (contact department about offerings).  For explanations of course elements see the Key to Course Descriptions.

Cancer Biology (CBIO)  Department Info

CBIO 496J -- Frontiers in Medical Research  (1 unit)
Description:  Current translational medical research presented in a seminar format by a variety of faculty research teams consisting of a clinical physician scientist and a basic scientist. Focus is on current research, relevant issues, historical perspectives and personal experience.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
May be repeated:  for credit 8 times (maximum 9 enrollments).
Identical to:  CBA 496J, MCB 496J.
May be convened with:  CBIO 596J.
Usually offered:  Fall, Spring.

CBIO 510 -- Gene Therapy and Molecular Engineering  (3-4 units)
Description:  Course covers gene delivery systems (viral and non-viral), applications of gene therapy in disease states such as monogenic deficiencies, cancer and infectious diseases. Immune responses to cancer gene therapy and molecular engineering of biologically active molecules will be emphasized.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  IMB 519; undergraduate immunology and basic cell and molecular biology.
Typical structure:  1 hour discussion, 3 hours lecture.
Identical to:  IMB 510; IMB is home department.
Usually offered:  Fall.

CBIO 515 -- Basic Human Pathology  (4 units)
Description:  Biochemical, structural, and functional changes in cells, tissues, and organs, which cause and are caused by diseases. For graduate students training for a career in biomedical research.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  open to all graduate students.
Typical structure:  3 hours lecture, 3 hours laboratory.
Identical to:  PATH 515; PATH is home department.
Usually offered:  Spring.

CBIO 530 -- Proteins and Nucleic Acids as Drug Targets  (3 units)
Description:  [Taught alternate years beginning Spring 2005]. The course will be coordinated through the Medicinal Chemistry Division of Pharmacology & Toxicology and will be Team Taught. Each semester four to five topics will be chosen for which the core areas of (chemistry, biochemistry, and medicinal chemistry) have been brought to bear on a specific biological question. Faculty, from the core areas, will lecture on each topic and lead discussions. Students will present material and lead discussions.
Grading:  Regular grades are awarded for this course: A B C D E.
Identical to:  PHSC 530; PHSC is home department.
Usually offered:  Spring.

CBIO 550 -- Drug Disposition and Metabolism  (2 units)
Description:  Principles of absorption, distribution and excretion of drugs, with emphasis on mechanisms of drug metabolism.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  PCOL 602A.
Identical to:  PCOL 550; PCOL is home department.
Usually offered:  Spring.

CBIO 551 -- Molecular Mechanisms of Carcinogenesis  (3 units)
Description:  Physical and chemical carcinogenesis. Special emphasis will be upon molecular aspects of the interaction of the carcinogenic agents with mammalian cells and the subsequent mutagenic and metabolic consequences of such interactions. The topics of oncogene activation and tumor suppressor gene inactivation induced by carcinogens during multi-stage carcinogenesis will be emphasized. The molecular biology techniques used in the study of carcinogenesis will also be covered.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  consent of department.
Identical to:  IMB 551, RONC 551.
Usually offered:  Fall.

CBIO 555 -- Cancer Therapeutics  (3 units)
Description:  Fundamental biological aspects of physical, chemical and biological therapies for cancer.
Grading:  Regular grades are awarded for this course: A B C D E.
Identical to:  CBA 555, IMB 555, MEDI 555, RONC 555.
Usually offered:  Spring.

CBIO 561 -- Cancer Biology Clinical Experience  (2 units)
Description:  Students will learn about the most common types of cancer and the four major clinical disciplines that are primarily responsible for diagnosing and treating patients with cancer. The course will be focused around a series of clinical experiences in which individual or small groups of students will observe a clinician in the practice of pathology, radiation oncology, medical oncology, and surgical oncology focused on one of the four major U.S. cancers, breast, colorectal, prostate, and lung cancer. Students will meet for one hour per week (12 weeks) with the course coordinator(s) and clinical faculty for didactic instruction on common types of cancer, lectures by clinicians in the major clinical disciplines, discussion of clinical observations and experiences, and to facilitate the scheduling of the clinical experiences. Students will be responsible for arranging a total of 12 hours of Clinical Experience Assignments with the assistance of the course coordinators, consisting of 8 hours of core assignments (4 assignments, 2 hours each) and 4 hours of elective assignments (1 – 2 hours each). Students will select from a variety of elective clinical experience assignments, observe a multidisciplinary case discussion conference in the major clinical subspecialties on a monthly basis, and learn about therapeutic development in cancer.
Grading:  Regular grades are awarded for this course: A B C D E.
Usually offered:  Fall, Spring.

CBIO 562 -- Tumor Immunology  (3 units)
Description:  The immunological mechanisms involved in host responses to tumors, with emphasis on the delineation of cellular interactions between immune cells and tumor cells that may result in tumor progression or rejection.
Grading:  Regular grades are awarded for this course: A B C D E.
Identical to:  IMB 562; IMB is home department.
Usually offered:  Fall.

CBIO 578 -- Signal Transduction in Molecular Medicine  (3 units)
Description:  Advanced treatment of the biochemistry and molecular biology of disease, considering both genomic and environmental factors.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  BIOC 462A, BIOC462B, or consent of instructor.
Identical to:  BIOC 578; BIOC is home department.
Usually offered:  Spring.

CBIO 589 -- Cancer Genetics  (3 units)
Description:  Understanding of correlations of molecular biology/chromosomal change in human cancer and the role of genetic change in progression and metastasis of cancer.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  ECOL 320, MCB 320.
May be repeated:  for credit 1 time (maximum 2 enrollments).
Identical to:  GENE 589, IMB 589, MCB 589.
Usually offered:  Fall.

CBIO 595A -- Oncogenes and Signal Transduction  (1 unit)
Description:  The exchange of scholarly information and/or secondary research, usually in a small group setting. Instruction often includes lectures by several different persons. Research projects may or may not be required of course registrants.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
Prerequisite(s):  open to graduate students in biological discipline, exceptionally qualified undergraduates.
Identical to:  BIOC 595A; BIOC is home department.
Usually offered:  Fall.

CBIO 595B -- Scientific Writing Strategies, Skills and Ethics  (2 units)
Description:  Provide students with skills to write/communicate effectively for a variety of scientific audiences; including scientific journals, funding institutions, potential employers as well as administration in academia and industry.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
Identical to:  PHCL 595B; PHCL is home department.
Usually offered:  Fall.

CBIO 595C -- Cancer Biology Colloquium  (1 unit)
Description:  This course will give Cancer Biology graduate students and Cancer Biology faculty an opportunity to effectively communicate research findings and journal articles.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
Prerequisite(s):  non-majors must contact instructor before enrolling.
May be repeated:  for credit 11 times (maximum 12 enrollments).
Usually offered:  Fall, Spring.

CBIO 595G -- Cancer Biology: Focus on Breast Cancer  (1 unit)
Description:  This a graduate-level journal club which will focus on the biology of cancer with a specific focus on breast cancer-related peer-reviewed research articles.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
May be repeated:  for credit 6 times (maximum 7 enrollments).
Identical to:  MCB 595G; MCB is home department.
Usually offered:  Fall.

CBIO 596H -- Cancer Biology Series  (1 unit)
Description:  University faculty and national and international invited speakers present cancer-related research seminars for this series. This seminar series is attended by basic and clinical faculty, postdoctoral fellows, graduate students and research staff. The seminars are also broadcast to the Phoenix UA College of Medicine, the Translational Genomics Research Institute (TGEN) and the Arizona Cancer Center/Greater Phoenix Campus. Graduate students taking this series for credit are required to ask three questions during the course of the semester.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
May be repeated:  for credit 2 times (maximum 3 enrollments).
Usually offered:  Fall.

CBIO 596I -- Molecular Cardiovascular Biology  (3 units)
Description:  The development and exchange of scholarly information, usually in a small group setting. The scope of work shall consist of research by course registrants, with the exchange of the results of such research through discussion, reports, and/or papers.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
May be repeated:  for credit 2 times (maximum 3 enrollments).
Identical to:  SURG 596I; SURG is home department.
Usually offered:  Fall.

CBIO 596J -- Frontiers in Medical Research  (1 unit)
Description:  Current translational medical research presented in a seminar format by a variety of faculty research teams consisting of a clinical physician scientist and a basic scientist. Focus is on current research, relevant issues, historical perspectives and personal experience. Graduate-level requirements include a one page summary for one of the seminars outlining recent discoveries and their clinical relevance.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
May be repeated:  for credit 8 times (maximum 9 enrollments).
Identical to:  CBA 596J, MCB 596J.
May be convened with:  CBIO 496J.
Usually offered:  Fall, Spring.

CBIO 599 -- Independent Study  (1-5 units)
Description:  Qualified students working on an individual basis with professors who have agreed to supervise such work. Graduate students doing independent work which cannot be classified as actual research will register for credit under course number 599, 699, or 799.
Grading:  Alternative grades are awarded for this course: S P C D E.
May be repeated:  an unlimited number of times, consult your department for details and possible restrictions.
Usually offered:  Fall, Spring, Summer.

CBIO 602A -- General and Systems Toxicology  (3 units)
Description:  Survey of tissue and organ system effects of environmental chemicals. Introduction to adsorption, distribution, metabolism, and elimination of chemicals; toxicology of liver, lung, kidney, central nervous system, skin, reproductive systems, hematopoeitic system, and immune system. Introduction to carcinogenesis and developmental toxicology.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  organic chemistry, two semesters of biology and one semester of biochemistry.
Identical to:  PCOL 602A; PCOL is home department.
Usually offered:  Fall.

CBIO 602B -- Biotoxicology Laboratory  (1 unit)
Description:  Proper use of animals in toxicology and pharmacology research; focuses on organ specific toxicities.
Grading:  Regular grades are awarded for this course: A B C D E.
Identical to:  PCOL 602B; PCOL is home department.
Usually offered:  Fall.

CBIO 610 -- Molecular and Cellular Toxicology  (3 units)
Description:  Molecular and cellular mechanisms of injury by environmental chemicals. Content includes reactive intermediates and oxidants, DNA and protein adducts, DNA repair, rotooncogene activation and tumor suppressor gene inactivation, apoptosis and cell death mechanisms, mechanisms of molecular mutagenesis, stress responses, signaling cascades, cell cycle controls, cell-cell communication and intercellular signalling in injury, and chemical and molecular biomarkers of exposure and injury.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  PCOL 602A.
Identical to:  PCOL 610; PCOL is home department.
Usually offered:  Fall, Spring.

CBIO 615A -- Cancer Epidemiology and Prevention  (3 units)
Description:  An overview of the current issues and methods in cancer epidemiological studies. Issues and methods used in cancer surveillance, international studies, observational studies, and intervention trials will be covered.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  EPID 573A; Prerequisite or Concurrent registration, EPID 576A.
Identical to:  EPID 615A; EPID is home department.
Usually offered:  Fall.

CBIO 628A -- Steroid & Lipoproteins: Structure, Metabolism & Funct., Relation to Hum. Disease  (3 units)
Description:  [Taught alternate odd-numbered years]. Biochemistry and metabolism of sterols and lipoproteins in mammalian systems; regulation of the biosynthesis and catabolism of sterols and lipoproteins in health and abnormalities related to disease; and dietary regulators of sterol and lipoprotein metabolism as relted to cardiovascular disease risk and prevention.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  BIOC 460 or BIOC 462A-BIOC 462B, N SC 602.
Identical to:  N SC 628A; N SC is home department.
Usually offered:  Spring.

CBIO 630A -- Cellular Communications and Signal Transduction  (3 units)
Description:  Principles of molecular signaling regulating membrane, cytoplasmic, and nuclear events in eukaryotic cells. Topics include extracellular signals, intracellular transduction pathways, modulation of cell signaling, and biological processes controlled by specific signaling pathways.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  BIOC 462A, BIOC 462B, BIOC 511.
May be repeated:  for a total of 6 units of credit.
Identical to:  PCOL 630A; PCOL is home department.
Usually offered:  Fall, Spring.

CBIO 630B -- Cellular Communications and Signal Transduction  (3 units)
Description:  Principles of molecular signaling regulating membrane, cytoplasmic, and nuclear events in eukaryotic cells. Topics include extracellular signals, intracellular transduction pathwyas, modulation of cell signaling, and biological processes controlled by specific signaling pahways.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  BIOC 462A, BIOC 462B.
Identical to:  PCOL 630B; PCOL is home department.
Usually offered:  Fall.

CBIO 631 -- Pharmacogenetics/Pharmacogenomics  (2 units)
Description:  Pharmacogenetics is the study of the effect of variation in a single gene on response to a therapeutic agent. Pharmacogenomics extends pharmacogenetics to include the effects of multiple genes and genome wide analysis. Topics include changes in gene expression induced by chemicals, how genetic information impacts the development and use of drugs as well as ethical, legal and social issues associated with using genetic information.
Grading:  Regular grades are awarded for this course: A B C D E.
Prerequisite(s):  BIOC460, PSIO 480.
Identical to:  PCOL 631; PCOL is home department.
Usually offered:  Fall.

CBIO 681 -- Introduction to Cancer Biology Research  (2 units)
Description:  Supervised research experience in the laboratories of individual faculty members.
Grading:  Regular grades are awarded for this course: A B C D E.
May be repeated:  for credit 4 times (maximum 5 enrollments).
Usually offered:  Fall, Spring, Summer.

CBIO 695A -- Research Conference  (1 unit)
Description:  This course will be used for research laboratory meetings and one-on-one research advisor/student meetings.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
May be repeated:  for credit 20 times (maximum 21 enrollments).
Usually offered:  Fall, Spring, Summer.

CBIO 695C -- Readings in Cancer Immunology  (1-2 units)
Description:  This course will focus on the analysis and discussion of current basic and clinical immunological studies of cancer in the literature and on the search for ways to control the disease. Immunological surveillance plays an important role in cancer. Dysregulation of the immune system contributes to the poorer outcome in the disease.
Grading:  Regular or alternative grades can be awarded for this course: A B C D E or S P C D E.
Prerequisite(s):  MIC 419.
Identical to:  IMB 695C; IMB is home department.
Usually offered:  Spring.

CBIO 799 -- Independent Study  (1-5 units)
Description:  Qualified students working on an individual basis with professors who have agreed to supervise such work. Graduate students doing independent work which cannot be classified as actual research will register for credit under course number 599, 699, or 799.
Grading:  Alternative grades are awarded for this course: S P C D E.
May be repeated:  an unlimited number of times, consult your department for details and possible restrictions.
Usually offered:  Fall, Spring, Summer.

For descriptions of medical student electives, see the College of Medicine Electives Manual.

CBIO 800 -- Research  (1-15 units)
Description:  Research course limited to medical students. Goals:involvement in a cancer-related research project of special interest to the student.
Grading:  Medical grades are awarded for this course: S P F K.
May be repeated:  for a total of 12 units of credit.
Usually offered:  Spring, Summer, Fall.

CBIO 896J -- Frontiers in Medical Research  (1 unit)
Description:  Current translational research presented by a variety of faculty research teams consisting of a clinical physician scientist and a basic scientist. Current research, relevant issues, historical perspectives and personal experience will be presented and discussed.
Grading:  Medical grades are awarded for this course: S P F K.
May be repeated:  for credit 8 times (maximum 9 enrollments).
Identical to:  MED 896J.
Usually offered:  Fall, Spring.

CBIO 900 -- Research  (1-9 units)
Description:  Individual research, not related to thesis or dissertation preparation, by graduate students.
Grading:  Alternative grades are awarded for this course: S P C D E K.
May be repeated:  an unlimited number of times, consult your department for details and possible restrictions.
Usually offered:  Fall, Spring, Summer.

CBIO 910 -- Thesis  (1-9 units)
Description:  Research for the master's thesis (whether library research, laboratory or field observation or research, artistic creation, or thesis writing). Maximum total credit permitted varies with the major department.
Grading:  Alternative grades are awarded for this course: S P E K.
May be repeated:  an unlimited number of times, consult your department for details and possible restrictions.
Usually offered:  Fall, Spring, Summer.

CBIO 920 -- Dissertation  (1-9 units)
Description:  Research for the doctoral dissertation (whether library research, laboratory or field observation or research, artistic creation, or dissertation writing).
Grading:  Alternative grades are awarded for this course: S P E K.
May be repeated:  an unlimited number of times, consult your department for details and possible restrictions.

CBIO 930 -- Supplementary Registration  (1-6 units)
Description:  For students who have completed all course requirements for their advanced degree programs. May be used concurrently with other enrollments to bring to total number of units to the required minimum.
Grading:  a Grade of K is awarded for this course except for the final term.
May be repeated:  an unlimited number of times, consult your department for details and possible restrictions.
Usually offered:  Fall, Spring, Summer.