The University of Arizona  1993-95 General Catalog

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Pharmaceutical Sciences (PHSC)
Pharmacy Building, Room 228
(520) 626-7265

Professors James Blanchard, Jack R. Cole (Emeritus), Arnold R.
Martin, Michael B. Mayersohn, William A. Remers, Karl H. Schram,
Samuel H. Yalkowsky, Joseph A. Zapotocky (Emeritus)

Associate Professors Sherry (Hsiao-Hui) Chow, Joseph J. Hoffmann
(Arid Lands Resource Sciences), Neil E. MacKenzie (Biochemistry),
Barbara N. Timmermann (Arid Lands Resource Sciences)

The Department of Pharmaceutical Sciences includes the academic
disciplines of pharmaceutical chemistry,
biopharmaceutics/pharmacokinetics, pharmaceutics, and
pharmacognosy. Please consult the College of Pharmacy section of
this catalog for undergraduate admission and degree requirements.

The Master of Science and Doctor of Philosophy degrees with a
major in pharmaceutical sciences are available. Concentration
within the major include pharmaceutical chemistry,
biopharmaceutics/pharmacokinetics, pharmaceutics and
pharmacognosy.  For admission and degree requirements, please see
the Graduate Catalog.

A student must be enrolled in the College of Pharmacy before
taking any pharmaceutical science course required in the
professional curriculum, except as approved by the department.

The department participates in the honors program.

302. Physical Pharmacy (4) I Discussion of the physical and
chemical factors that relate to the development of pharmaceutical
products and drug delivery systems. Emphasis is placed on newly
emerging technologies and an industrial perspective. P, PHYS
102b, 180b, CHEM 103b, 104b.

306. Physical Pharmacy Lab (1) I. P, CR 302.

307. Dosage Form Design (2) II Application of physical-chemical
principles to pharmaceutical dosage forms, including a discussion
of the biopharmaceutical considerations which influence the
efficacy of pharmaceutical formulations. P, 302, 306.

309. Dosage Form Design Lab (1) II. P, CR 307.

400. Pharmaceutical Calculations (2) I (Identical with PHPR 400)

407. Pharmacokinetics (4) I Quantitative description of the
processes of drug absorption, distribution and elimination and
factors affecting those processes. Application of kinetic
principles to chronic drug administration. P, 307. (Identical
with PHPR 407) May be convened with 507.

408a-408b. Pharmacokinetics Discussion (1-1) I II Discussion
related to the application of pharmacokinetic principles with
case-study examples. CR, 407 for 408a, 485 for 408b. (Identical
with PHPR 408a-408b) May be convened with 508a-508b.

424. Antibiotics (2) I (Identical with PHPR 424)

437a-437b. Medicinal Chemistry and Pharmacognosy (4-4)
Relationships between the chemical structure and  physiological
activity, incompatibilities and stability of the organic and
inorganic compounds obtained from natural and synthetic sources;
essentials of pharmacognosy, including biologicals. P, 307, CHEM
241b, 243b. May be convened with 537a-537b.

438. Pharmaceutical Analysis (2) II Modern methods and
instrumentation used for qualitative and quantitative
determination of drugs and metabolites. P, CHEM 323.

485. Advanced Clinical Pharmacokinetics (3) II (Identical with
PHPR 485) May be convened with 585.

507. Pharmacokinetics (4) I For a description of course topics,
see 407. Graduate-level requirements include an in-depth analysis
of a pharmacokinetic problem. P, 307. (Identical with PHPR 507)
May be convened with 407.

508a-508b. Pharmacokinetics Discussion (1-1) I II For a
description of course topics, see 408a-408b. Graduate-level
requirements include an in-depth analysis of a pharmacokinetic
problem. CR, 407 for 408a, 485 for 408b. (Identical with PHPR
508a-508b) May be convened with 408a-408b.

512. Quantitative Structure-Activity Relationships (3) 1993-94
Approaches to the quantification of pharmacological actions of
drugs on the basis of chemical structure.

527. Antineoplastic Drugs (2) II Discovery and development of
natural and synthetic antineoplastic drugs; preclinical screening
and toxicity evaluation; phase I, II, and III clinical studies in
humans. P, 437b or CR.

537a-537b. Medicinal Chemistry and Pharmacognosy (4-4) For a
description of course topics, see 437a-437b. Graduate-level
requirements include extensive use of the current literature and
emphasis on drug design principles. P, 307, CHEM 241b, 243b. May
be convened with 437a-437b.

585. Advanced Clinical Pharmacokinetics (3) II (Identical with
PHPR 585) May be convened with 485.

596. Seminar
a. Pharmaceutical Chemistry (1) [Rpt./5] I II
b. Pharmaceutical Chemistry Research (1) [Rpt./5] I II
c. Pharmaceutics Research (1 to 2) [Rpt./5] I II Open to majors
d. Pharmaceutics (1) [Rpt./5 units] I II

601. Advanced Physical Pharmacy (3) II 1994-95 Applications of
physical chemistry to pharmacy. P, physical pharmacy or physical
chemistry course.

602. Physicochemical Factors Influencing Drug Action (3) I 1993-
94 The role of acid-base equilibria, dissolution, and
complexation in influencing drug formulation and drug action. P,

603. Pharmaceutics of Solid Systems (3) II 1994-95 Rates of phase
transformations, properties of particulate systems, solid state
kinetics, physics of powder compression. P, CHEM 480b.

606. Industrial Manufacturing Pharmacy (3) II Pharmaceutics as
applied to various aspects of industrial pharmacy. Field trips.

609a-609b. Pharmacokinetics (3-3) 1993-94 Quantitative treatment
of kinetics of drug absorption, distribution, metabolism,
excretion and pharmacologic response, including development of
mathematical models for these processes and use of digital
computer for simulation and nonlinear regression analysis. P,

630a-630b. Advanced Organic Medicinals (3-3) 1994-95 Rational
drug design, receptor site theories, mechanism of drug action,
and metabolic pathways of medicinal agents; chemical and
enzymatic synthesis of important pharmaceuticals. P, 437b, PCOL

632a-632b. Natural Medicinal Products (3-3) 1993-94 Origin and
isolation of steroidal and alkaloidal drugs and other natural
products of interest. P, 437b, PCOL 471b.

634. Biomedical Applications of Mass Spectrometry (3) I 1993-94
Principles of mass spectrometry including instrumental design,
interpretation of spectra, and applications to biomedical and
related problems. P, CHEM 241b.

815. Pharmacy Subspecialty
l. Research (3-10) I II S 15-30L. P, or CR, 10 units of PHPR 810.
(Identical with PHPR 815l, which is home.)


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