The University of Arizona  1993-95 General Catalog

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Pharmacology and Toxicology (PCOL/TOX)
Pharmacy Building, Room 236
(520) 626-2823

(Department, College of Pharmacy)

Professors I. Glenn Sipes, Head, Timothy Bowden (Radiation
Oncology), Dean E. Carter, Lincoln Chin (Emeritus), Paul F.
Consroe, James R. Halpert, Wayburn S. Jeter (Emeritus), Hugh E.
Laird II, Albert L. Picchioni (Emeritus), Findlay E. Russell,
Theodore Tong (Pharmacy Practice)

Associate Professor Charlene A. McQueen

Assistant Professors Cliff D. Crutchfield (Health Education),
William S. Dalton (Internal Medicine), Robert T. Dorr, Daniel C.
Liebler, John Regan, John Sullivan (Emergency Medicine and
Pharmacology), Mark Van Ert (Health Education)

Pharmacology is the science concerned with all aspects of the
actions of drugs and other chemicals on living systems. Its
primary aim is the discovery of chemical mechanisms by which
cellular and molecular functions are regulated for the purpose of
understanding how existing drugs act and to develop new drugs for
treatment of diseases. The broad scope of interests of
pharmacology ranges from the study of intermolecular reactions of
chemical constituents of cells with drugs to the effects of
chemicals in our environment on entire populations. In
conjunction with other departments in the University, the
department participates in an interdisciplinary graduate program
leading to the Doctor of Philosophy degree with a major in
pharmacology and toxicology. (See Graduate Interdisciplinary
Program in Pharmacology and Toxicology). For admission and degree
requirements, please see the Graduate Catalog.

Toxicology is the science concerned with the harmful effects of
chemicals (including drugs) on living systems. The toxicology
program offers a curriculum leading to the Master of Science
degree with a major in toxicology. The program prepares students
for careers in hospital laboratories, police crime laboratories,
medical examiners' offices, industrial hygiene laboratories, and
toxicology laboratories in industry, government, and
universities. The broad scope of interests in toxicology ranges
from determining the mechanisms by which chemicals produce
adverse biological effects to identification, and quantification
of hazards resulting from occupational and/or environmental
exposure to chemicals. For admission and degree requirements,
please see the Graduate Catalog.

Industrial hygiene is the applied science concerned with the
anticipation, recognition, evaluation, and control of chemical
and physical agents that can affect health status in occupational
and environmental settings. An industrial hygiene concentration
is offered within the M.S. toxicology program. The concentration
prepares students for professional practice in a wide range of
both private and public sector organizations. For admission and
degree requirements, please see the Graduate Catalog.

The department participates in the honors program.

Pharmacology (PCOL)

195. Colloquium
a. Foundations of Modern Pharmacology (1) I

401. Human Gross Anatomy (3) II (Identical with ANAT 401)

471a-471b.  Fundamentals of Pharmacology (4-4) Comprehensive
study of the biochemical, physiological, and therapeutic effects
of drugs, including mechanisms of drug action and drug toxicity,
and drug literature evaluation. 3R, 3L. P, ANAT 401, BIOC 460,
PSIO 480, 481; PHSC 437a-437b. (Identical with TOX 471a-471b) May
be convened with 571a-571b.

472. Nursing Pharmacology (3) I II Pharmacodynamics,
pharmacology, and adverse effects of  commonly used drugs, with
emphasis on clinical applications. Not available for elective
credit in the College of Pharmacy or graduate credit in
pharmacology-toxicology doctoral programs. May be convened with
572.

474. Clinical Toxicology (2) I Prevention, characteristics,
diagnosis and rational management of diseases caused by drug
overdose, toxic household products, poisonous plants, venomous
animals, environmental and industrial toxicants. P, 472 or 471b,
PHSC 407. (Identical with TOX 474) May be convened with 574.

571a-571b.  Fundamentals of Pharmacology (4-4) For a description
of course topics, see 471a-471b. Graduate-level requirements
include an in-depth research paper on a current topic. P, ANAT
401, BIOC 460, PSIO 480, 481; CR, PHPR 475a-475b and PHSC 437a-
437b. (Identical with TOX 571a-571b) May be convened with 471a-
471b.

572. Nursing Pharmacology (3) I II For a description of course
topics, see 472. Graduate-level requirements include a term paper
on nursing pharmacology. May be convened with 472.

574. Clinical Toxicology (2) I For a description of course
topics, see 474. Graduate-level requirements include an in-depth
research paper on a current topic in toxicology and/or a format
presentation on a current subject to the class. P, 472 or 471b,
PHSC 407. (Identical with TOX 574) May be convened with 474.

596. Seminar
a. Advanced Graduate Research (1-3) [Rpt./3] I II (Identical with
PHCL 596a, which is home)

620. Principles of Pharmacology (3) I (Identical with PHCL 620)

653. Neuropharmacology (3-4) II Role of various neurochemicals in
the peripheral and central nervous systems and the effects of
drugs on the nervous system, including their actions at receptors
and their influence on synthesis, storage, and release of
neurotransmitters. P, PHCL 501 or PCOL. 471b, 561a, 596.
(Identical with PHCL 653 and TOX 653)

695. Colloquium
a. Research Conference (1-4) [Rpt.] I II

696. Seminar
a. Student Research (1) [Rpt./4] II (Identical with PHCL 696a,
which is home)

815. Pharmacy Subspecialty
l. Research (5) I II S 15-30L. P or CR, 10 units of 810.
(Identical with PHPR 815l, which is home.)

Toxicology (TOX)

408. Insect Toxicology (3) II 1993-94 (Identical with ENTO 408)
May be convened with 508.

410. Physical Exposures (3) II (Identical with OSH 410) May be
convened with 510.

423. Mechanisms of Disease (4) II (Identical with V SC 423) May
be convened with 523.

437. Vertebrate Physiology (4) I (Identical with ECOL 437)

462a-462b.  Biochemistry (3-3) (Identical with BIOC 462a-462b)
Honors section available for (4) honors credits. May be convened
with 562a-562b.

466. Physiology Laboratory (3) II (Identical with ECOL 466) May
be convened with 566.

471a-471b.  Fundamentals of Pharmacology (4-4) (Identical with PCOL. 471a-471b) May be convened with 571a-571b.

474. Clinical Toxicology (2) I (Identical with PCOL. 474) May be
convened with 574.

480. Human Physiology (4) II (Identical with PSIO 480) May be
convened with 580.

481. Physiology Laboratory (1) II (Identical with PSIO 481)

485. Industrial Ventilation (3) II Design and evaluation of
industrial ventilation systems. Emphasis is on level evaluation
of industrial contaminants. Five laboratory exercises and course
design project. 3R, 1L. May be convened with 585.

486. Fundamentals of Industrial Hygiene (3) I (Identical with OSH
486) May be convened with 586.

487. Advanced Industrial Hygiene and Safety (3) II (Identical
with OSH 487) May be convened with 587.

501. The Pharmacological Basis of Therapeutics (6) II (Identical
with PHCL 501) P, PSIO 601 and graduate course equivalent to BIOC
801.

502. Industrial Hygiene Instrumentation and Analysis (2-4) I
(Identical with OSH 502)

508. Insect Toxicology (3) II 1993-94 (Identical with ENTO 508)
May be convened with 408.

509. Statistics for Research (4) I II (Identical with STAT 509)

510. Physical Exposures (3) II (Identical with OSH 510) May be
convened with 410.

512. Hazardous Materials (2-4) I (Identical with OSH 512)

523. Mechanisms of Disease (4) II (Identical with V SC 523) May
be convened with 423.

550. Drug Disposition and Metabolism (2) II (Identical with PHCL
550)

551. Molecular Biology of Pharmacological Agents (3) I 1993-94
(Identical with PHCL 551)

554. Industrial Toxicology and Chemical Exposures (2-4) I
Principles of toxicology related to industry; dose response;
mechanisms of toxicity; hazard evaluation principles; toxicology
of major classes of industrial compounds. P, 6 units each of
biological science and organic chemistry.

560. General Biochemistry (5) I II (Identical with BIOC 560)

562a-562b.  Biochemistry (3-3) (Identical with BIOC 562a-562b)
May be convened with 462a-462b.

566. Physiology Laboratory (3) II (Identical with ECOL 566) May
be convened with 466.

571a-571b.  Fundamentals of Pharmacology (4-4) (Identical with
PCOL 571a-571b) May be convened with 471a-471b.

574. Clinical Toxicology (2) I (Identical with PCOL. 574) May be
convened with 474.

576. Environmental Toxicology (3) II Toxicity of natural toxins
and of agricultural and industrial chemicals, with emphasis on
air and water pollutants; decision-making in environmental
issues. P, 6 units of biology and of organic chemistry; CHEM 325,
326. (Identical with ENTO 576 and PHCL 576)

580. Human Physiology (4) II (Identical with PSIO 580) May be
convened with 480.

581. Physical Laboratory (3) II (Identical with PSIO 581)

582. Immunotoxicology (2) I Broad overview of the immune system,
with emphasis on how chemicals affect the immune system
(immunomodulation) and the role of the immune system in chemical-
induced tissue injury/allergic responses. P, 602a-602b, MIC 419R,
MBIM 567. (Identical with MBIM 582 and PHCL 582)

585. Industrial Ventilation (3) II For description of course
topics, see 485. Graduate-level requirements include additional
in-depth materials and written papers. May be convened with 485.

586. Fundamentals of Industrial Hygiene (3) I (Identical with OSH
586) May be convened with 486.

587. Advanced Industrial Hygiene and Safety (3) II (Identical
with OSH 587) May be convened with 487.

596. Seminar
a. Advanced Toxicology (1-2) [Rpt./3] I
b. Current Concepts in Toxicology (1-2) [Rpt./3] II

601. Analytical Instrumentation and Techniques (2-4) I Lecture
and laboratory in the qualitative and quantitative determination
of toxic substances in the environment and body fluids. Modern
instrumental techniques will be employed whenever appropriate.
Lecture may be taken separately by non-majors. 2R, 6L. P. CHEM
325, 326. (Identical with PHCL 601)

602a-602b.  Biotoxicology (3-1) 602a: I Lecture. Mechanisms of
organ directed toxicities in animals. Chemical carcinogenesis,
teratogenesis and mutagenesis. Open to non-majors. P, two
semesters of ecology. 602b: II Laboratory. Proper use of animals
in toxicology and pharmacology research; focuses on organ
specific toxicities. (Identical with PHCL 602a-602b)

610. Topics in Advanced Toxicology (1-3) I II Current
developments in toxicology including: chemical carcinogenesis,
mutagenesis and teratogenesis; behavioral toxicology; inhalation
toxicology; toxicokinetics; metabolism and environmental
toxicology. P, 601, 602a-602b.

620. Principles of Pharmacology (3) I (Identical with PHCL 620)

653. Neuropharmacology (3-4) II (Identical with PCOL 653)

696. Seminar
a. Student Research (1) [Rpt./4] II (Identical with PHCL 696a,
which is home)
Pharmacology and Toxicology

College of Medicine, Room 5103
(520) 626-7912

Graduate Interdisciplinary Program in Pharmacology and Toxicology
Committee:

Professors David L. Kreulen, Chair, David S. Alberts (Cancer
Center), H. Vasken Aposhian (Molecular and Cellular Biology), G.
Tim Bowden (Radiation Oncology), Klaus Brendel (Pharmacology),
Rubin Bressler (Internal Medicine), Burnell R. Brown
(Anesthesiology), Dean E. Carter (Pharmacology and Toxicology),
Paul F. Consroe (Pharmacology and Toxicology), Thomas P. Davis
(Pharmacology), A. Jay Gandolfi (Anesthesiology), Marilyn Halonen
(Pharmacology), James R. Halpert (Pharmacology and Toxicology),
Ryan J. Huxtable (Pharmacology), David G. Johnson (Internal
Medicine), Hugh E. Laird, II (Pharmacology and Toxicology),
Eugene Morkin (Heart Center), John D. Palmer (Pharmacology),
Frank Porreca (Pharmacology), Garth Powis (Cancer Center),
Charles W. Putnam (Surgery), William R. Roeske (Internal
Medicine), Findlay E. Russell (Pharmacology and Toxicology), I.
Glenn Sipes (Pharmacology and Toxicology), Henry I. Yamamura
(Pharmacology)

Associate Professors William S. Dalton (Internal Medicine),
Robert D. Dorr (Cancer Center), Timothy C. Fagan (Internal
Medicine), Laurel Fisher (Pharmacology), Edward D. French
(Pharmacology), Charlene A. McQueen (Pharmacology and
Toxicology), John B. Sullivan (Surgery)

Assistant Professors Josephine Y. Lai (Pharmacology), Douglas F.
Larson (Surgery), Daniel C. Liebler (Pharmacology and
Toxicology), Ronald Lynch (Pharmacology), John W. Regan
(Pharmacology and Toxicology)

Research Professor Ronald R. Watson (Family and Community
Medicine)

Research Associate Professors Ron Lukas (Pharmacology), Thomas L.
Smith (Pharmacology)

Research Assistant Professor Mark L. Witten (Pediatrics)

Research Lecturer John Gilkey (Arizona Research Laboratory)

The Graduate Interdisciplinary Program in Pharmacology and
Toxicology offers a graduate program leading to the Doctor of
Philosophy degree with a major in pharmacology and toxicology.
The program has a faculty of forty-one from the departments of
Pharmacology, Pharmacology and Toxicology, Anesthesiology, Cancer
Center, Molecular and Cellular Biology, Radiation Oncology,
Surgery, Internal Medicine, and the Arizona Research Laboratory.
Faculty members have research interests in carcinogenesis/cancer
chemotherapy, cardiovascular pharmacology, endocrine
pharmacology, environmental toxicology, immunopharmacology,
molecular/biochemical pharmacology, molecular toxicology,
neuropharmacology, and toxicology. Students in the Ph.D. program
may choose a major track in pharmacology or toxicology; several
areas of concentration are available in either track. The Ph.D.
degree is awarded upon successful completion of a research
project that culminates in an original and significant scientific
contribution.

For course descriptions, please see entries in this catalog for
Pharmacology (Department, College of Medicine) and Pharmacology
and Toxicology (Department, College of Pharmacy). For information
on graduate programs and admission requirements, please see the
Graduate Catalog.
 

 


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