The University of Arizona  1993-95 General Catalog

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Molecular and Cellular Biology (MCB)
Life Sciences South Building, Room 444
(520) 621-7560

Professors Samuel Ward, Head, H. Vasken Aposhian, Hans Bohnert
(Biochemistry), Don Bourque (Biochemistry), George T. Bowden
(Radiation Oncology), Robert P. Erickson (Pediatrics), Wayne R.
Ferris (Emeritus), William J. Grimes (Biochemistry), Mac E.
Hadley (Anatomy), Richard B. Hallick (Biochemistry), John
Hildebrand (Arizona Research Laboratory), Henry Koffler
(Biochemistry, Microbiology and Immunology), Brian Larkins (Plant
Sciences), John Little (Biochemistry), Neil H. Mendelson, David
W. Mount, Gene Myers (Computer Science), Nobuyoshi Shimizu, Paul
Sypherd, Hans Van Etten (Plant Pathology)

Associate Professors Danny Brower, Gail Burd (Anatomy), Carol
Dieckmann (Biochemistry), Jennifer D. Hall, Martha Hawes (Plant
Pathology), Martinez J. Hewlett, Thomas J. Lindell, Elizabeth
Vierling (Biochemistry)

Assistant Professors Alison Adams, Herman Gordon (Anatomy), Lynn
Manseau, Roger L. Miesfeld (Biochemistry), Karen Oishi, Roy
Parker, Mary Rykowski (Anatomy), Scott Selleck (Arizona Reseach
Laboratories), Ted Weinert

The University Department of Molecular and Cellular Biology
offers the Bachelor of Science, Master of Science, and Doctor of
Philosophy degrees with a major in molecular and cellular
biology. The department will only admit graduate students whose
stated objective is the Doctor of Philosophy degree.

The major: 181R, 182, 320, 410, 411, 462a, and at least three
units of an upper-division laboratory course (such as 413, 473 or
494); CHEM 103a-103b, 104a-104b, 241a-241b, 243a-243b; PHYS 104a-
104b; MATH 125a or 124 and 125b. Writing emphasis course
requirements can be met by taking 404, 470, 473, 455 or 498H.
With the assistance of a major advisor, the student must select a
minimum of 30 units, including at least 6 units of upper-division
molecular and cellular biology courses. All majors are encouraged
to undertake independent research and they are strongly advised
to include CHEM 480a-480b in their program.

Biology teaching major: Students interested in teaching secondary
school biology, which includes molecular and cellular biology,
should see the list of required courses under Department of
Ecology and Evolutionary Biology.

The minor: The department has a structured split minor involving
chemistry, physics, and mathematics.

The department participates in the honors program. Core courses
all have additional honors credit.

181L. Introductory Biology Laboratory (1) I Laboratory exercises
presenting techniques and fundamental principles of modern
biology. Designed to complement the information concurrently
presented in 181R. P, 181R or CR, 181R. (Identical with BIOC
181L, ECOL 181L, MIC 181L)

181R. Introductory Biology I (3) I Introduction to the cell and
its properties, basic genetics, the immune system, recombinant
DNA technology with illustrations from bacteria, plants, animals
and humans. High school biology/chemistry recommended. Honors
section available for 4 units. P, CR 181L. (Identical with BIOC
181R, ECOL 181R, MIC 181R)

182. Introductory Biology II (4) II (Identical with ECOL 182) 

195. Colloquium
a. Great Experiments in Microbiology (1) I II (Identical with MIC
195a)
b. Biotechnology (1) I II (Identical with BIOC 195a)
c. Society and Science (1) I II (Identical with BIOC 195c, which
is home)

320. Genetics (4) I (Identical with ECOL 320)

404. Contemporary Biology in Human Affairs (3) II Advances in
biomedical research will be reviewed and their ethical, social
and legal implications discussed. P, one course in BIOC or
biology; botany not acceptable.

410. Cell Biology (3) II The molecular basis of the structure and
function of animal, plant and prokaryotic cells with emphasis on
experimental analysis. P, 181, 182, 462a, recommend 320 and CR
411. (Identical with BIOC 410 and MIC 410) Honors section
available for (4) honors credits.

411. Molecular Biology (3) II Mechanisms of genome replication,
genetic recombination, DNA repair, gene expression and
regulation. P, 181, BIOC 462a. recommend 320 (Identical with BIOC
411 and MIC 411) May be convened with 511. Honors section
available for (4) honors credits).

413. Somatic Cell and Molecular Genetics Laboratory (3) I Modern
lab. techniques for genetic and molecular analyses of mammalian
cells in culture. 6L. P, 181. May be convened with 513.

415. Somatic Cell and Molecular Genetics (2) II Modern concepts
of eucaryotic cell genetics and molecular mechanisms of cell
growth control. P, 181. (Identical with GENE 415) May be convened
with 515.

416. Computer Analysis of Sequences (3) II Analysis of protein
and DNA sequence information using computer methods. Consult
instructor for appropriate prerequisites before enrolling
(Identical with BIOC 416, ECOL 416 and GENE 416). May be convened
with 516.

421a-421b. Microbiological Techniques (3-3) (Identical with MIC
421a-421b)

428. Microbial Genetics (3) II (Identical with PL P 428)

429. General Virology (3) II (Identical with MIC 429)

437. Vertebrate Physiology (4) I (Identical with ECOL 437)

443. Insect Neurobiology (3) II (Identical with ENTO 443) May be
convened with 543.

455. Developmental Mechanisms (3) I Molecular and cellular
mechanisms of development, with emphasis on model systems. P, 181
and an advanced course in genetics, molecular or cell biology.
(Identical with BIOC 455)

456. Developmental Biology (3) I (Identical with ANAT 456) May be
convened with 556.

457. Experiments in Developmental Biology (4) II (Identical with
ANAT 457) May be convened with 557.

460. Plant Physiology (4) I (Identical with PL S 460) May be
convened with 560.

461. Neurobiology (4) I Cellular, molecular, and development
biology of nerve cells, synapses, and neural systems. (Identical
with NRSC 461) P, 181, 182 or equivalents.

462a-462b. Biochemistry (3) II (Identical with BIOC 462a-462b)
Honors section available for (4) honors credits.

466. Physiology Laboratory (3) II (Identical with ECOL 466) May
be convened with 566.

467R. Endocrinology (3) II (Identical with ANAT 467R) May be
convened with 567R.

469. Developmental Neurobiology (2) II Development of the nervous
systems of invertebrates and vertebrates from embryonic stages to
the adult. P, 8 units of biology.

470. The Cell and the Environment (3) I The molecular and
cellular responses to the environment. P, MCB 410 and/or
Biochemistry.

471. Human Embryology (4) II (Identical with ANAT 471) May be
convened with 571.

473. Recombinant DNA Methods and Applications (4) II Relevant
techniques for the isolation, purification and cloning of genes
in E. Coli hosts. Eucaryotic lambda genomic DNA clones will be
characterized by restriction mapping, hybridization analysis, and
sequence analysis. 2R, 6L. P, BIOC 462a, CR 411. (Identical with
BIOC 473, GENE 473, MIC 473, and PL S 473)

496. Seminar
a. Developmental Biology (1) [Rpt./6] I II Consult instructor
before enrolling. May be convened with 596a.
b. Cell Biology (1) [Rpt./6] I II Consult instructor before
enrolling. May be convened with 596b.
d Molecular Genetics (1) [Rpt./6] I II Consult instructor before
enrolling. May be convened with 596d.
e Molecular Bioology (1) [Rpt./6] I II Consult instructor before
enrolling. May be convened with 596e.

497. Workshop.

Special Tutoring Workshop (1-3) [Rpt] I II Open to senior MCB and
Biochemistry majors only. Consult department before enrolling.
(Identical with BIOC 497a)

501. Molecular and Cellular Biology (4) I P, formal admission to
the Ph.D./M.D. program and permission of the course director.

505. Eukaryotic DNA Replication (3) [Rpt./1] I 1994-95 (Identical
with CBIO 505)

510. Plant Molecular Biology (3) II 1994-95 (Identical with BIOC
510)

511. Molecular Biology (3) II For a description of course topics,
see 411. Graduate-level requirements include attending an
additional lecture hour per week to discuss independent research,
and to perform at a level 10% above undergraduate students. MCB
majors should not take this course for graduate credit. P, 462a
and consult department before enrolling. (Identical with BIOC 511
and MBIM 511) May be convened with 411.

513. Somatic Cell and Molecular Genetics Laboratory (3) I For a
description of course topics, see 413. Graduate-level
requirements include an oral presentation. P, 181. May be
convened with 413.

515. Somatic Cell and Molecular Genetics (2) II For a description
of course topics, see 415. Graduate-level requirements include
reading papers from the current literature. P, 181. (Identical
with GENE 515) May be convened with 415.

516. Computer Analysis of Sequences (3) II For description of
course topics, see 416. Graduate students will be required to
conduct a research project, submit a written report, and give a
presentation in class. (Identical with BIOC 516, ECOL 516 and
GENE 516). May be convened with 416.

520. Pathways and Signals in Cells (3) II (Identical with BIOC
520).

543. Insect Neurobiology (3) II (Identical with ENTO 543) May be
convened with 443.

545. Concepts in Genetic Analysis (3) I Methods of genetic
analysis including mutant isolation, genetic and physical
mapping, reverse genetics, evolutionary mechanisms, molecular
variation and genomic evolution. P, introductory undergraduate
genetics course or biology course. (Identical with BIOC 545, ECOL
545, GENE 545)

550. Topics in Pigment Cell Biology (2) I (Identical with ANAT
550)

555. Molecular Mechanisms of Development (3) II Detailed
examination of molecular, genetic and cellular approaches to
selected problems in developmental biology. P, 545, 568 or
consult department before enrolling. (Identical with BIOC 555 and
GENE 555)

556. Developmental Biology (3) I (Identical with ANAT 556) May be
convened with 456.

557. Experiments in Developmental Biology (4) II (Identical with
ANAT 557) May be convened with 457.

558. Advanced Subjects in Endocrinology (2) [Rpt.] I (Identical
with ANAT 558)

560. Plant Physiology (4) I (Identical with PL S 560) May be
convened with 460.

562. Plant Intermediary Metabolism (3) II 1993-94 (Identical with
PL S 562)

564. Plant Growth and Development (3) II 1993-94 (Identical with
PL S 564)

566. Physiology Laboratory (3) II (Identical with ECOL 566) May
be convened with 466.

567R. Endocrinology (3) II (Identical with ANAT 567R) May be
convened with 467R.

568. Nucleic Acids (4) I (Identical with BIOC 568)

569. Topics in Gene Regulations (2) II 1994-95 (Identical with
BIOC 569)

571. Human Embryology (4) II (Identical with ANAT 571) May be
convened with 471.

572. Biological Regulation (4) I (Identical with BIOC 572).

574. Advances in Mammalian Genetics (2) [Rpt./1] I 1994-95
(Identical with BIOC 574)

575. Special Topics in Biological Imaging (2) (Identical with
ANAT 575)

577. Principles of Cell Biology (4) II (Identical with ANAT 577)

582. Topics in Neural Development (2) II 1993-94 (Identical with
NRSC 582)

583. Topics in Neural Plasticity (2) II 1993-94 Reading and
discussion of primary literature on cellular, biochemical,
physiological, and structural changes that occur on the adult
nervous system. P, a course in neurobiology, consult department
before enrolling. (Identical with ANAT 583 and NRSC 583)

584. Cellular Neurobiology (2) II 1993-94 (Identical with ANAT
584)

586. Intracellular Messengers (2) I 1993-94 (Identical with NRSC
586)

587. Biology of Neurological Disease (3) II 1993-94 (Identical
with NRSC 587)

588. Principles of Cellular and Molecular Neurobiology (4) I
(Identical with NRSC 588)

589. Cancer Genetics and Cytogenetics (3) I 1993-94 (Identical
with CBIO 589)

595. Colloquium
a. Topics in Molecular Biology (1) [Rpt./6] I II Open to majors
only.
d. Special Topics in Cell Biology (2) [Rpt./3] II (Identical with
CBIO 595d, which is home)

596. Seminar
a. Developmental Biology (1) [Rpt./6] I II Consult instructor
before enrolling. May be convened with 496a.

b. Cell Biology (1) [Rpt./6] I II Consult instructor before
enrolling. May be convened with 496b.
c. Concepts in Cellular Differentiation (2) I (Identical with
ANAT 596c)
d. Molecular Genetics (1) [Rpt./6] I II Consult instructor before
enrolling. May be convened with 496d.

e. Molecular Bioology (1) [Rpt./6] I II Consult instructor before
enrolling. May be convened with 496e.

597. Workshop
a. Recombinant DNA Techniques (2) S (Identical with BIOC 597a,
which is home)

601. Molecular and Cellular Biology (4) I Acquire a basic
understanding of modern genetics, molecular biology and cell
biology, and learn how to apply that understanding to human
disease. Open to students in the Masters degree program in
Genetic Counseling only. (Identical with GENE 601).

612. Biological Electron Microscopy (4) I Provides theoretical
background and practical experience in transmission and scanning
electron microscopy that are necessary for the efficient and
effective application of ultrastructural and cytochemical
techniques as research tools. 2R, 6L. P, one college level course
in each of physics, chemistry and biology (Identical with ANAT
612, AN S 612, BIOC 612, ENTO 612, MIC 612, PATH 612, PSIO 612,
PL P 612, V SC 612)

621. Molecular, Plant, Microbe Interactions (3) I 1993-94
(Identical with PL P 621)

695. Colloquium
a. Current Topics in Plant Biology (1) [Rpt./3] I II (Identical
with PL P 695a, which is home)
e. Science, Society and Ethics (1) II (Identical with GENE 695e
and NRSC 695e)

696. Seminar
a. Developmental Biology (1) [Rpt./6] I II To be taken only when
596a repeated course limit has been met.
b. Cell Biology (1) [Rpt./6] I II P, 596b. To be taken only when
596b repeated course limit has been met.
d.  Molecular Genetics (1) [Rpt./6] I II P, 596d. To be taken
only when 596d repeated course limit has been met.
e. Molecular Bioology (1) [Rpt./6] I II P, 596e. To be taken only
when 596e repeated course limit has been met.

697. Workshop
a. Scientific Infrastructure (2) I II Open to majors only.

761. Laboratory Rotation I (2) [Rpt./1] I II Research project
with graduate faculty for 8 weeks, 15 hours per week. Open to
majors only.

762. Laboratory Rotation II (2) [Rpt./1] I II Research project
with graduate faculty for 8 weeks, 15 hours per week. Open to
majors only.

763. Laboratory Rotation III (2) I II Research project with
graduate faculty for 8 weeks, 15 hours per week. Open to majors
only.

801. Molecular and Cellular Biology (4) I Freshman medical
students only.

 


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