The University of Arizona  1993-95 General Catalog

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Biochemistry (BIOC)
Biological Sciences West Building, Room 357
(520) 621-5770

Professors Michael A. Wells, Head, Hans J. Bohnert (Molecular and
Cellular Biology, Plant Sciences), Don P. Bourque (Molecular and
Cellular Biology), Michael F. Brown (Chemistry), Herbert E.
Carter (Emeritus), Michael A. Cusanovich, Leslie S. Forster
(Emeritus), Eugene W. Gerner (Radiation Oncology), Darrel E. Goll
(Animal Sciences), William J. Grimes, Richard B. Hallick, David
J. Hartshorne (Animal Sciences), Mark R. Haussler, John G.
Hildebrand (Molecular and Cellular Biology; Division of
Neurobiology/ARL), Victor J. Hruby (Chemistry), Richard G.
Jensen, Henry Koffler (Microbiology and Immunology; Molecular and
Cellular Biology), John H. Law, John W. Little, David W. Mount
(Molecular and Cellular Biology), David F. O'Brien (Chemistry),
John A. Rupley, Eugene G. Sander, Marc E. Tischler, Gordon
Tollin, Henry I. Yamamura (Pharmacology; ARL)

Associate Professors Danny L. Brower (Molecular and Cellular
Biology), Louise M. Canfield, Carol L. Dieckmann, Robert J.
Gillies, Jennifer D. Hall (Molecular and Cellular Biology),
Martinez J. Hewlett (Molecular and Cellular Biology), Neil E.
MacKenzie (Pharmaceutical Sciences), Elizabeth Vierling

Assistant Professors Mark S. Dodson, Roger L. Miesfeld, William
R. Montfort

Biochemistry provides the fundamentals for study of the molecular
principles in biology, medicine, and the health sciences and
agricultural sciences. Teaching and research in biochemistry are
carried out in several locations in the University. The faculty
members listed above constitute the University Department of
Biochemistry, which is responsible for instruction in
biochemistry in the Colleges of Agriculture, Arts and Science,
and Medicine. These programs serve as an excellent background for
graduate study in biochemistry or the many health-related
sciences, including a major preprofessional program for
qualification for professional schools of medicine, dentistry and
osteopathy.

The University Department of Biochemistry offers the Bachelor of
Science, Bachelor of Science in Agriculture, Bachelor of Arts,
Master of Science and Doctor of Philosophy degrees with a major
in biochemistry. Applicants are not admitted directly to the
Master of Science program. The degree is awarded only in rare
instances when individuals admitted to Ph.D. programs terminate
early.

The major for the B.S.: CHEM 103a-103b, 104a-104b, or 105a-105b,
241a-241b, 243a-243b, 480a and 480b or 481, MATH 125a-125b, 223;
PHYS 104a-104b; BIOC 181R, 182, 411, 462a-462b, 494, 496a (2
units), and 6 upper-division units in biology, chemistry,
mathematics, or physics, exclusive of individual studies. All
students will participate in a senior research practicum (494)
for a minimum of six units after taking 462a-462b and 411. Senior
research is conducted in the laboratory of a faculty member with
approval of the advisor, and must include the writing of a senior
thesis.

The major for the B.A.: CHEM 103a-103b, 104a-104b, or 105a-105b,
241a-241b, 243a-243b, 480a; MATH 125a; PHYS 102a-102b; BIOC 181R,
182; 462a-462b, 411, 496a (2 units), 499 (one unit), and 6 upper-
division units in biology, chemistry, mathematics, or physics,
exclusive of individual studies. All B.A. students will sign up
for BIOC 499 for a minimum of one hour. The credit will be given
for the writing of a senior research paper under the direction of
a faculty advisor. Those who apply for medical school should take
ECOL 320 in preparation for the Medical College Admission Test
(MCAT).

The minor for both undergraduate degrees consists of CHEM 103a-
103b, 104a-104b, 241a-241b, 243a-243b, MATH 124 or 125a plus the
following course sequences in Biochemistry: 1) BIOC 462a (3),
BIOC 462b (3), and BIOC 411 (3); or, 2) BIOC 460 (5) plus one
other course approved by a faculty member.

Biology teaching major: Students interested in teaching secondary
school biology, which includes biochemistry, should see the list
of required courses under the Department of Ecology and
Evolutionary Biology.

The department participates in the honors program.

181L. Introductory Biology Laboratory (1) I (Identical with MCB
181L)

181R. Introductory Biology I (3) I (Identical with MCB 181)

182. Introductory Biology II (4) II (Identical with ECOL 182)

195. Colloquium
a. Great Experiments in Microbiology (1) I II (Identical with MIC
195a, which is home)
b. Biotechnology (1) I II (Identical with MIC 195b and MCB 195b)

c. Society and Science (1) I II (Identical with ECOL 195c, MCB
195c, MIC 195c)

295. Colloquium
a. Opportunities in Biological Science (1) [Rpt./4 units]

296. Proseminar
a. Biological Chemistry (1) II (Identical with CHEM 296a, which
is home)

410. Cell Biology (3) II (Identical with MCB 410) 

411. Molecular Biology (3) II (Identical with MCB 411) May be
convened with 511.

416. Computer Analysis of Sequences (3) II (Identical with MCB
416) May be convened with 516.

433. Teaching Biology Labs (2) II Preparation and teaching of lab
and field exercises for high school biology. Includes brief high
school teaching experiences. Designed for prospective high school
biology teachers. 1R, 3L. Field trip. Open to prospective biology
teachers only. P, 12 units of biology. (Identical with ENTO 433)
May be convened with 533.

443. Research Animal Methods (3) I (Identical with V SC 443) May
be convened with 553.

455. Developmental Mechanisms (3) I (Identical with MCB 455) 

460. General Biochemistry (5) I II Fundamentals of biochemistry,
including proteins, nucleic acids, enzymes, carbohydrates and
lipids and their metabolic relationships. Open to nonmajors only.
P, 181, CHEM 241b. (Identical with CHEM 460 and N FS 460) May be
convened with 560.

462a-462b. Biochemistry (3-3) Introduction to the properties and
metabolism of proteins, nucleic acids, enzymes, carbohydrates and
lipids. Designed primarily for majors and minors in chemistry,
biochemistry and biology. P, CHEM 241b, CR, CHEM 322, 325. For
MCB students, MCB 410 is prerequisite to 462b. (Identical with
CHEM 462a-462b, MCB 462a-462b, and TOX 462a-462b). Honors section
available for (4) honors credits. May be convened with 562a-562b.

463.  iochemistry Laboratory (2) II Introduction to
experimentation with biochemical systems, processes and compounds
of biochemical importance. 1R, 5L. P, 460 or 462a, and CR 462b.
May be convened with 563.

473. Recombinant DNA Methods and Techniques (4) II (Identical
with MCB 473)

496. Seminar
a. Biochemistry (1) [Rpt./1] I II Open to majors only. P, 462a or
CR. Consult department before enrolling. Writing-Emphasis Course.
P,  Satisfaction of the upper-division writing-proficiency
requirement (see "Writing-Emphasis Courses" in the Academic
Policies and Graduation Requirements section of this catalog).

497. Workshop. 
Special Tutoring Workshop (1-3) I II Open to senior MCB and
Biochemistry majors only. Consult department before enrolling.
(Identical with MCB 497a, which is home).

501. Medical Biochemistry (5) P, MCB 501/801, formal admission to
the Ph.D./M.D. program, and permission of the course director.

502. Professionalizing Presentation Skills (1) I II Methods for
students in any discipline to augment their proficiency in the
preparation, delivery and self-evaluation of presentations.

505. Eukaryotic DNA Replication (3) [Rpt./1] I 1994-95 (Identical
with CBIO 505)

510. Plant Molecular Biology (3) II 1994-95 (Identical with PL S
510)

511. Molecular Biology (3) II (Identical with MCB 511) May be
convened with 411.

516. Computer Analysis of Sequences (3) II (Identical with MCB
516) May be convened with 416.

520. Pathways and Signals in Cells (3) II Objectives are to
outline various mechanisms of intracellular signaling. This
includes the chemical and structural bases for the action of
second messengers, e.g. calcium and cyclic nucleotides. P, BIOC
460, 462a or equivalent; open to undergraduates with permission.
(Identical with MCB 520, AN S 520).

533. Teaching Biology Labs (2) II For description of course
topics, see 433. Graduate-level requirements include an
additional project. (Identical with ENTO 533) May be convened
with 433.

543. Research Animal Methods (3) I (Identical with V SC 543) May
be convened with 443.

545. Concepts in Genetic Analysis (3) I (Identical with MCB 545)

555. Molecular Mechanisms of Development (3) II (Identical with
MCB 555)

560. General Biochemistry (5) I II For a description of course
topics, see 460. Graduate-level requirements include additional
in-depth material. Open to nonmajors only. P, CHEM 241b.
(Identical with CHEM 560 and TOX 560). May be convened with 460.

561a-561b. Introduction to Biochemical Literature (1-1) I II
Discussion of the biochemical literature aimed at helping the
student evaluate and report the published literature. Primarily
for first year graduate students planning a career in
biochemistry and desiring to prepare themselves for continued
study. P, CR 462a-462b. 561a is not prerequisite to 561b.
(Identical with CHEM 561a-561b)

562a-562b. Biochemistry (3-3) For a description of course topics,
see 462a-462b. Graduate-level requirements include additional in-
depth material. P, CHEM 241b, CR, CHEM 322, 325. (Identical with
CHEM 562a-562b and TOX 562a-562b) May be convened with 462a-462b.

563. Biochemistry Laboratory (2) II For a description of course
topics, see 463. Graduate-level requirements include additional
in-depth material. P, 460 or 462a, and CR 462b. May be convened
with 463.

565. Enzymes (3) I Advanced consideration of enzyme structure and
function. P, 462a, CHEM 480b. (Identical with CHEM 565).

568. Nucleic Acids (4) I Chemistry, structure, and function of
nucleic acids; replication, transcription translation, gene
organization, regulation of gene expression and organelle nucleic
acids. Both procaryotic and eucaryotic systems will be
considered. P, BIOC 411/511, MCB 411/511, or an equivalent
introductory molecular biology course, or permission of the
instructor. (Identical with GENE 568, MCB 568 and N FS 568)

569. Topics in Gene Regulation (2) II 1994-95 Behavior of gene
regulatory systems in prokaryotes and eukaryotes. Knowledge of
mechanisms is assumed and discussed when needed, but emphasis is
on regulatory circuitry. Most lectures will be student
presentations. (Identical with MCB 569) P, 568 or permission of
instructor.

572. Biological Regulation (4) I Advanced treatment of the
biochemical aspects of biological regulation in eukaryotic cells.
Topics to be discussed include regulation of cellular metabolism,
growth and cell division in both plant and animal cells. P, 462a-
462b or consult department before enrolling (Identical with MCB
572)

574. Advances in Mammalian Genetics (2) [Rpt./1] I 1994-95
Student participation in the presentation and discussion of
current literature covering recent advances in the molecular
analysis of mammalian genetic loci. P, undergraduate courses in
genetics and molecular biology. (Identical with GENE 574 and MCB
574)

577. Biological Structure II (3) 1993-94 II Advanced study of
macromolecular structure; theory, methods, and results of x-ray
crystallography and NMR. P, 585 or permission of instructor.

585. Biological Structure I (4) II Introduction to the current
understanding and methods used for study of the structure,
thermodynamics, and dynamics of proteins, nucleic acids, and
membranes. P, CR, 462a-462b, CHEM 480a-480b. (Identical with CHEM
585)

586. Intracellular Messengers (2) I 1993-94 (Identical with NRSC
586)

588. Principles of Cellular and Molecular Neurobiology (4) I
(Identical with NRSC 588)

595. Colloquium
a. Oncogenes and Signal Transduction(1) [Rpt./2] Open to graduate
students in biological discipline, exceptionally qualified
undergraduates (Identical with CBIO 595a)

597. Workshop
a. Recombinant DNA Techniques (2) S Open to high school biology
teachers only. R/L. (Identical with MCB 597a)
c. Current Topics for Biology Teaching (1) [Rpt./29] I II
Designed to inform in-service and pre-service biology teachers of
new developments in the biological sciences. Topics vary with
each offering. Open to in-service and pre-service teachers only.
P, 18 units of biological sciences.

612. Biological Electron Microscopy (4) I (Identical with MCB
612)

621. Molecular, Plant, Microbe Interaction (3) I 1993-94
(Identical with PL P 621)

665. Analysis & Purification of Proteins (3) II 1993-94
(Identical with AN S 665)

681. Introduction to Biochemical Research (1-5) I II Supervised
research experiences in the labs. of individual faculty members.
3 or 6L. Open only to first-year majors. P, CR 561a-561b.

696. Seminar
a. Biochemistry I (1-3) I [Rpt./9 units]
b. Biochemistry II (1-3) II [Rpt./9 units]

800. Research (1-16) Yr.

801. Medical Biochemistry (6) II Comprehensive treatment of
general biochemistry with clinical applications, oriented toward
human biology. Includes protein and nucleotide chemistry and
metabolism, enzymology, lipid and carbohydrate metabolism,
metabolic regulation, biochemical nutrition, biochemical
endocrinology and related topics. Includes clinical case studies,
clinical discussions, tutorials and computer-assisted
instruction.

891. Preceptorship
a. Biochemistry (3-12) [Rpt./12 units]

Biology
Three departments (Ecology and Evolutionary Biology, Microbiology
and Immunology, and Molecular and Cellular Biology) teach and do
research in biology. They share a common core of courses. Details
of their programs may be found under their respective listings.
 

 


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